Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate
SN 6
CAS: 415697-08-4
Molecular Formula: C20H22N2O5S
Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate - Names and Identifiers
Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate - Physico-chemical Properties
| Molecular Formula | C20H22N2O5S |
| Molar Mass | 402.46 |
| Density | 1.285±0.06 g/cm3(Predicted) |
| Boling Point | 581.2±50.0 °C(Predicted) |
| pKa | 6.63±0.60(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| In vitro study | SN 6 is a selective Na + /Ca 2+ exchanger inhibitor, which inhibits the initial rate of 45 Ca 2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC 50 values of 2.9 ± 0.12, 16 ± 1.1, and 8.6 ± 0.27 μM. SN 6 (up to 30 μM) also less potently inhibits muscarinic acetylcholine receptor, with a higher IC 50 of 18 μM. SN 6 (0.3-30 μM) completely inhibits the initial rate of Na + i -dependent 45 Ca 2+ uptake into Na + -loaded sarcolemmal vesicles in a dose dependent manner (IC 50 , 5.3 ± 0.37 μM). SN 6 (0.3-10 μM) dose-dependently protects against the hypoxia/reoxygenation-induced LDH release in parental LLC-PK1 cells and NCX1 transfectants but not in K229Q transfectants. SN 6 (1-30 μM) suppresses the bidirectional outward and inward I NCX in a concentration-dependent manner, with IC 50 values of 2.3 μM and 1.9 μM, respectively. SN 6 also inhibits bidirectional current (I NCX ) in a [Na + ]i concentration-dependent manner, with IC 50 values of 3.4 μM, 2.3 μM, and 1.1 μM at 10 mM, 20 mM, and 30 mM [Na + ]i, respectively. SN 6 inhibits hypoxia/reoxygenation-induced LDH release with an IC 50 value of 0.63 ± 0.15 μM in NCX1 transfectants. |
Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.485 ml | 12.424 ml | 24.847 ml |
| 5 mM | 0.497 ml | 2.485 ml | 4.969 ml |
| 10 mM | 0.248 ml | 1.242 ml | 2.485 ml |
| 5 mM | 0.05 ml | 0.248 ml | 0.497 ml |
Last Update：2024-01-02 23:10:35
Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate - Reference Information
| biological activity | SN-6 is a selective Na /Ca2 exchanger (NCX) inhibitor. NCX1, NCX2 and NCX3 were inhibited by SN-6, and the corresponding IC50 values were 2.9 μm, 16 μm and 8.6 μm, respectively. SN-6 abrogates acetylcholine (ACh)-induced vasodilation. |
| Target | Value |
| NCX1 (Cell-free assay) | 2.9 μM |
| NCX3 (Cell-free assay) | 8.6 μM |
| NCX2 (Cell-free assay) | 16 μM |
Last Update：2024-04-10 22:29:15
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Product Name: SN 6 Visit Supplier Webpage Request for quotationCAS: 415697-08-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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